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  1. Breast cancer is the most frequently diagnosed cancer, and no effective treatment solution has yet been found. The number of studies based on the research of novel natural compounds in the treatment of breast ...

    Authors: Demet Cansaran-Duman, Sevcan Yangın and Betül Çolak

    Citation: Biological Research 2021 54:37

    Content type: Research article

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  2. Melatonin 2-hydroxylase (M2H) is the first enzyme in the catabolism pathway of melatonin, which catalyzes the production of 2-hydroxymelatonin (2-OHM) from melatonin. The content of 2-hydroxymelatonin in plant...

    Authors: Yuexin Zhang, Jing Wang, Xiugui Chen, Xuke Lu, Delong Wang, Junjuan Wang, Shuai Wang, Chao Chen, Lixue Guo, Waqar Afzal Malik, Yapeng Fan, Cun Rui, Ruifeng Cui, Qinqin Wang, Yuqian Lei and Wuwei Ye

    Citation: Biological Research 2021 54:36

    Content type: Research article

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  3. Urushiols are pro-electrophilic haptens that cause severe contact dermatitis mediated by CD8+ effector T-cells and downregulated by CD4+ T-cells. However, the molecular mechanism by which urushiols stimulate inna...

    Authors: Rodrigo Pacheco, Sergio A. Quezada, Alexis M. Kalergis, María Inés Becker, Jorge Ferreira and Alfredo E. De Ioannes

    Citation: Biological Research 2021 54:35

    Content type: Research article

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  4. Xanthophyllomyces dendrorhous is a basidiomycete yeast that naturally produces the red–orange carotenoid astaxanthin, which has remarkable antioxidant properties. The biosynthesis of carotenoids and sterols share...

    Authors: Melissa Gómez, Marcelo Baeza, Víctor Cifuentes and Jennifer Alcaíno

    Citation: Biological Research 2021 54:34

    Content type: Review

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  5. The antisense noncoding mitochondrial RNAs (ASncmtRNAs) derive from the mitochondrial 16S gene. Knockdown of these transcripts with chemically-modified antisense oligonucleotides induces proliferative arrest, ...

    Authors: Nicole Farfán, Nicole Sanhueza, Macarena Briones, Luis O. Burzio and Verónica A. Burzio

    Citation: Biological Research 2021 54:33

    Content type: Short report

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  6. Deep breathing (DB) and handgrip (HG) exercise -with and without circulatory occlusion (OC) in muscle-, have been shown to have beneficial effects on cardiovascular function; however, the combination of these ...

    Authors: David C. Andrade, Claudia Melipillan, Camilo Toledo, Angélica Rios-Gallardo, Noah J. Marcus, Fernando C. Ortiz, Gonzalo Martinez, Paula Muñoz Venturelli and Rodrigo Del Rio

    Citation: Biological Research 2021 54:32

    Content type: Research article

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  7. Heart failure (HF) is the leading cause of death in western countries. Cardiac dysfunction is accompanied by skeletal alterations resulting in muscle weakness and fatigue. Exercise is an accepted interventiona...

    Authors: Julia Böttner, Sarah Werner, Volker Adams, Sarah Knauth, Angela Kricke, Holger Thiele and Petra Büttner

    Citation: Biological Research 2021 54:31

    Content type: Research article

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  8. This study aims to identify the effect of miR-146a-5p on trophoblast cell invasion as well as the mechanism in preeclampsia (PE).

    Authors: Pingping Peng, Huamei Song, Chenghong Xie, Wenfei Zheng, Huigai Ma, Dandan Xin, Jingqiong Zhan, Xiaoqing Yuan, Aihua Chen, Jing Tao and Jufang Qin

    Citation: Biological Research 2021 54:30

    Content type: Research article

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  9. Improving the nutritional condition of grapevine in spring to regulate bloom, fruit set, and yield is among the management goals of vineyards.

    Authors: Rouhollah Karimi, Abbas Saberi and Ali Khadivi

    Citation: Biological Research 2021 54:28

    Content type: Research article

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  10. Demethylzeylasteral (T-96) is a pharmacologically active triterpenoid monomer extracted from Tripterygium wilfordii Hook F (TWHF) that has been reported to exhibit anti-neoplastic effects against several types of...

    Authors: Dong-lin Yang, Ya-jun Zhang, Liu-jun He, Chun-sheng Hu, Li-xia Gao, Jiu-hong Huang, Yan Tang, Jie Luo, Dian-yong Tang and Zhong-zhu Chen

    Citation: Biological Research 2021 54:27

    Content type: Research article

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  11. Breast cancer (BC), a heterogeneous, aggressive illness with high mortality, is essentially a genomic disease. While the high-penetrance genes BRCA1 and BRCA2 play important roles in tumorigenesis, moderate- and ...

    Authors: Trinidad Arancibia, Sebastian Morales-Pison, Edio Maldonado and Lilian Jara

    Citation: Biological Research 2021 54:26

    Content type: Review

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  12. Peroxisome proliferator-activated receptor alpha (PPARα) is associated with diabetic retinopathy (DR), and the underlying mechanism is still unclear. Aim of this work was to investigate the mechanism of PPARα ...

    Authors: Ying Zhu, Xinru Wang, Xiaoyun Zhou, Lexi Ding, Dan Liu and Huizhuo Xu

    Citation: Biological Research 2021 54:25

    Content type: Research article

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  13. Accumulating evidence has demonstrated that the electroacupuncture (EA) stimulation could effectively alleviate neuropathic pain. The medial prefrontal cortex (mPFC) is a vital part of the cortical representat...

    Authors: Menghong Jiang, Xiaomei Chen, Liangping Zhang, Weiting Liu, Xiangmei Yu, Zhifu Wang and Meifeng Zheng

    Citation: Biological Research 2021 54:24

    Content type: Review

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  14. The Ras family of small Guanosine Triphosphate (GTP)-binding proteins (G proteins) represents one of the main components of intracellular signal transduction required for normal cardiac growth, but is also cri...

    Authors: Manuel Ramos-Kuri, Sri Harika Meka, Fabio Salamanca-Buentello, Roger J. Hajjar, Larissa Lipskaia and Elie R. Chemaly

    Citation: Biological Research 2021 54:23

    Content type: Review

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  15. Accumulated evidence demonstrates cisplatin, a recommended chemotherapy, modulating pro-survival autophagic response that contributes to treatment failure in lung cancer patients. However, distinct mechanisms ...

    Authors: Somruethai Sumkhemthong, Eakachai Prompetchara, Pithi Chanvorachote and Chatchai Chaotham

    Citation: Biological Research 2021 54:22

    Content type: Research article

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  16. Chagas disease is considered important and presents intense inflammatory and fibrotic processes induced by the perpetuation of the parasite in the affected tissues and organs. Therefore, it is necessary to inq...

    Authors: Martha Alicia Ballinas-Verdugo, Rogelio Frank Jiménez-Ortega, Eduardo Martínez-Martínez, Nancy Rivas, Erick Abraham Contreras-López, Roxana Carbó, Fausto Sánchez, Rafael Bojalil, Ricardo Márquez-Velasco, Fausto Sánchez-Muñoz and Ricardo Alejandre-Aguilar

    Citation: Biological Research 2021 54:21

    Content type: Research article

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  17. The current COVID-19 pandemic has already claimed more than 3.7 million victims and it will cause more deaths in the coming months. Tools that track the number and locations of cases are critical for surveilla...

    Authors: Raúl Arias-Carrasco, Jeevan Giddaluru, Lucas E. Cardozo, Felipe Martins, Vinicius Maracaja-Coutinho and Helder I. Nakaya

    Citation: Biological Research 2021 54:20

    Content type: Letter to the Editor

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  18. In the era of climate change, due to increased incidences of a wide range of various environmental stresses, especially biotic and abiotic stresses around the globe, the performance of plants can be affected b...

    Authors: Xiu-Peng Song, Krishan K. Verma, Dan-Dan Tian, Xiao-Qiu Zhang, Yong-Jian Liang, Xing Huang, Chang-Ning Li and Yang-Rui Li

    Citation: Biological Research 2021 54:19

    Content type: Review

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  19. The MVD gene mutations are identified in porokeratosis, which is considered a skin-specific autoinflammatory keratinization disease. However, the biological function of MVD gene remains largely unknown. Therefore...

    Authors: Wenghong Wong, Yike Huang, Zhuanbin Wu, Yu Kong, Jing Luan, Qiaoan Zhang, Jiewen Pan, Kexiang Yan and Zhenghua Zhang

    Citation: Biological Research 2021 54:17

    Content type: Research article

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  20. Recently, there is increasing awareness focused on the identification of naturally occurring anticancer agents derived from natural products. Manuka honey (MH) has been recognized for its biological properties...

    Authors: Heba R. Al Refaey, Al-Sayeda A. Newairy, Mayssaa M. Wahby, Chris Albanese, Mohamed Elkewedi, Muhammad Umer Choudhry and Ahmed S. Sultan

    Citation: Biological Research 2021 54:16

    Content type: Research article

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  21. Water stress is one of the serious abiotic stresses that negatively influences the growth, development and production of sugarcane in arid and semi-arid regions. However, silicon (Si) has been applied as an al...

    Authors: Krishan K. Verma, Xiu-Peng Song, Chhedi Lal Verma, Zhong-Liang Chen, Vishnu D. Rajput, Kai-Chao Wu, Fen Liao, Gan-Lin Chen and Yang-Rui Li

    Citation: Biological Research 2021 54:15

    Content type: Research article

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  22. Circular RNAs (circRNAs) has emerged as vital regulator involved in various diseases. In this study, we identified and investigated the potential circRNAs involved in gestational diabetes mellitus (GDM).

    Authors: Haitian Chen, Shaofeng Zhang, Yanxin Wu, Zhuyu Li, Dongyu Wang, Shiqin Cai and Zilian Wang

    Citation: Biological Research 2021 54:14

    Content type: Research article

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  23. Helicobacter pylori is detected by pathogen recognition receptors including toll-like receptors (TLR) and nucleotide-binding oligomerization domain (NOD)-like receptors, eliciting an innate immune response agains...

    Authors: Patricio Gonzalez-Hormazabal, Diana Pelaez, Maher Musleh, Marco Bustamante, Juan Stambuk, Raul Pisano, Hector Valladares, Enrique Lanzarini, Hector Chiong, Jose Suazo, Luis A. Quiñones, Nelson M. Varela, V. Gonzalo Castro, Lilian Jara and Zoltan Berger

    Citation: Biological Research 2021 54:13

    Content type: Research article

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  24. Multiple sclerosis (MS) is a central nervous system disease with a high disability rate. Modern molecular biology techniques have identified a number of key genes and diagnostic markers to MS, but the etiology...

    Authors: Xin Chen, Huiqing Hou, Huimin Qiao, Haolong Fan, Tianyi Zhao and Mei Dong

    Citation: Biological Research 2021 54:12

    Content type: Research article

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  25. Atherosclerosis (AS) is the most common type in cardiovascular disease. Due to its complex pathogenesis, the exact etiology of AS is unclear. circRNA has been shown to play an essential role in most diseases. ...

    Authors: Xiaohao Zhang, Junying Lu, Qinghua Zhang, Qiang Luo and Bin Liu

    Citation: Biological Research 2021 54:11

    Content type: Research article

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  26. Parkinson’s disease (PD) is a common age-related neurodegenerative disorder worldwide. This research aimed to investigate the effects and mechanism underlying long non-coding RNA metastasis-associated lung ade...

    Authors: Kefeng Lv, Yuhua Liu, Yanbing Zheng, Shaowen Dai, Peifeng Yin and Haifeng Miao

    Citation: Biological Research 2021 54:10

    Content type: Research article

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  27. PGF2α is essential for the induction of the corpus luteum regression which in turn reduces progesterone production. Early growth response (EGR) proteins are Cys2-His2-type zinc-finger transcription factor that...

    Authors: Meeti Punetha, Sai Kumar, Avishek Paul, Bosco Jose, Jaya Bharati, Arvind Sonwane, Jonathan A. Green, Kristin Whitworth and Mihir Sarkar

    Citation: Biological Research 2021 54:9

    Content type: Research article

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  28. This study aimed to investigate the potential role and molecular mechanism of lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in cerebral ischemia/reperfusion injury.

    Authors: Ying Jia, Lian Yi, Qianqian Li, Tingjiao Liu and Shanshan Yang

    Citation: Biological Research 2021 54:8

    Content type: Research article

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  29. Mitochondria play a significant role in plant cytoplasmic male sterility (CMS). In our previous study, mitochondrial complex I genes, nad4, nad5, and nad7 showed polymorphisms between the transgenic CMS line M2BS...

    Authors: Danfeng Tang, Fan Wei, Aziz Khan, Fazal Munsif and Ruiyang Zhou

    Citation: Biological Research 2021 54:6

    Content type: Research article

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  30. Early-life stress in the form of maternal separation can be associated with alterations in offspring neurodevelopment and brain functioning. Here, we aimed to investigate the potential impact of prolonged mate...

    Authors: Zdenka Drastichova, Vladimir Rudajev, Gergely Pallag and Jiri Novotny

    Citation: Biological Research 2021 54:4

    Content type: Research article

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  31. Testosterone regulates nutrient and energy balance to maintain protein synthesis and metabolism in cardiomyocytes, but supraphysiological concentrations induce cardiac hypertrophy. Previously, we determined th...

    Authors: Mayarling Francisca Troncoso, Mario Pavez, Carlos Wilson, Daniel Lagos, Javier Duran, Sebastián Ramos, Genaro Barrientos, Patricio Silva, Paola Llanos, Carla Basualto-Alarcón, B. Daan Westenbrink, Sergio Lavandero and Manuel Estrada

    Citation: Biological Research 2021 54:3

    Content type: Research article

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  32. The preventive and therapeutic medical utilization of this plant is an age-long practice across the globe. This study aimed to validate the impact of dark purple blossoms of basil (Ocimum basilicum L.) aqueous ex...

    Authors: Mariam Abdulaziz Alkhateeb, Wedad Refaiea Al-Otaibi, Qwait AlGabbani, Amena Ali Alsakran, Alaa Ahmed Alnafjan, Amani Mohammed Alotaibi and Wedad Saeed Al-Qahtani

    Citation: Biological Research 2021 54:2

    Content type: Research article

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  33. Neuronal apoptosis plays a critical event in the pathogenesis of early brain injury after subarachnoid hemorrhage (SAH). This study investigated the roles of Tauroursodeoxycholic acid (TUDCA) in attenuate neur...

    Authors: Huihui Wu, Nini Yu, Xia Wang, Yina Yang and Hui Liang

    Citation: Biological Research 2020 53:56

    Content type: Research article

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  34. Gunnera tinctoria has been collected by Mapuche-Pewenche people for food and medicinal purposes. The high polyphenol content of methanolic extract from G. tinctoria leaves with chemical constituents such as ellag...

    Authors: Constanza Sabando, Maité Rodríguez-Díaz, Walther Ide, Edgar Pastene, Marcia Avello, Mario Simirgiotis, Susana Rojas, Enrique Villarroel, Tiare Silva-Grecchi, Cristian Gutiérrez, Rebeca Bouza, Bárbara Cicchelli, Marcelo González and Saddys Rodríguez-Llamazares

    Citation: Biological Research 2020 53:55

    Content type: Research article

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  35. UV-B signaling in plants is mediated by UVR8, which interacts with transcriptional factors to induce root morphogenesis. However, research on the downstream molecules of UVR8 signaling in roots is still scarce...

    Authors: Meiting Du, Yanhong Wang, Huize Chen and Rong Han

    Citation: Biological Research 2020 53:54

    Content type: Research article

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  36. Our previous study indicated that aerobic exercise relieves cognitive impairment in patients with vascular cognitive impairment (VCI) via regulating brain-derived neurotrophic factor (BDNF), but the mechanism ...

    Authors: Jing Wang, Yali Niu, Huaying Tao, Mina Xue and Chunxiao Wan

    Citation: Biological Research 2020 53:53

    Content type: Research article

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  37. Chinese hamster ovary (CHO) cells are the most commonly used mammalian host cell in the commercial-scale production of biopharmaceutical proteins. Modification of genes involved in apoptosis may improve the pr...

    Authors: Fatemeh Safari, Safar Farajnia, Abbas Behzad Behbahani, Habib Zarredar, Mazyar Barekati-Mowahed and Hesam Dehghani

    Citation: Biological Research 2020 53:52

    Content type: Research article

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  38. Acupuncture, a therapy of traditional Chinese medicine, is confirmed to exert the therapeutic action on polycystic ovary syndrome (PCOS). However, the detailed therapeutic mechanisms of acupuncture in PCOS rem...

    Authors: Yan Peng, Xinming Yang, Xi Luo, Chunhong Liu, Xia Cao, Hongyan Wang and Liyuan Guo

    Citation: Biological Research 2020 53:50

    Content type: Research article

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  39. Although OIP5-AS1 has been characterized as an oncogenic lncRNA in many types of cancer, its role and underlying mechanism in ovarian carcinoma (OC) remains unknown. This study aimed to investigate the role of...

    Authors: Xingzhi Jiang, Zhongxue Ye, Yafen Jiang, Wen Yu and Qian Fang

    Citation: Biological Research 2020 53:49

    Content type: Research article

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  40. Psoriasis is a common chronic inflammatory skin disease. Keratinocytes hyperproliferation and excessive inflammatory response contribute to psoriasis pathogenesis. The agents able to attenuate keratinocytes hy...

    Authors: Jintao Gao, Fangru Chen, Huanan Fang, Jing Mi, Qi Qi and Mengjuan Yang

    Citation: Biological Research 2020 53:48

    Content type: Research article

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  41. Nitrogen is the main limiting nutrient after carbon, hydrogen and oxygen for photosynthetic process, phyto-hormonal, proteomic changes and growth-development of plants to complete its lifecycle. Excessive and ...

    Authors: Muhammad Anas, Fen Liao, Krishan K. Verma, Muhammad Aqeel Sarwar, Aamir Mahmood, Zhong-Liang Chen, Qiang Li, Xu-Peng Zeng, Yang Liu and Yang-Rui Li

    Citation: Biological Research 2020 53:47

    Content type: Review

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  42. Kidney cancer is one of the most common cancers in the world. It is necessary to clarify its underlying mechanism and find its prognostic biomarkers. Current studies showed that SHMT2 may be participated in se...

    Authors: Huan Wang, Tie Chong, Bo-Yong Li, Xiao-San Chen and Wen-Bo Zhen

    Citation: Biological Research 2020 53:46

    Content type: Original paper

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  43. Skeletal muscle has an important role in regulating whole-body energy homeostasis, and energy production depends on the efficient function of mitochondria. We demonstrated previously that AT-rich interactive d...

    Authors: Yuri Okazaki, Jennifer Murray, Ali Ehsani, Jessica Clark, Robert H. Whitson, Lisa Hirose, Noriyuki Yanaka and Keiichi Itakura

    Citation: Biological Research 2020 53:45

    Content type: Research article

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  44. Atherosclerosis (AS) is the main pathological basis of coronary heart disease, cerebral infarction and peripheral vascular disease, which seriously endanger people’s life and health. In recent years, long non-...

    Authors: Yi Liu, Xiyun Cui, Cong Wang and Sihai Zhao

    Citation: Biological Research 2020 53:44

    Content type: Research article

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