Table 4 Allele or genotype associated with breast cancer risk in miRNA SNPs included in this review
BC risk category | miRNA | SNP(s) | Risk allele or genotype | p-value | Countries | References |
|---|---|---|---|---|---|---|
Increased risk | 146a | rs2910164:G > C | C CG and GG C CC C C GC and CC CC | 0.03 < 0.05 0.04 < 0.001 0.03 0.0037 0.033 and 0.028 < 0.0001 | Brazil China China Iran Iran Iran Italy Pakistan | Brincas et al. 2020 [109] He et al. 2015 [56] Qi et al. 2015 [55] Mashayekhi et al. 2018 [69] Parchami Barjui et al. 2017 [76] Meshkat et al. 2016 [83] Pastrello et al. 2010 [98] Ahmad et al. 2019 [91] |
196a2 | rs11614913:C > T | T CT C C C CT | 0.024 0.04 0.01 0.011 0.02236 0.01 | Brazil India China China Iran Saudi Arabia | Linhares et al. 2012 [108] Bodal et al. 2017 [68] Qi et al. 2015 [55] Hu et al. 2009 [59] Najeti-Azar et al., 2018 [72] Alshtawi et al. 2012 [87] | |
499 | rs3746444:T > C or A > G | AG and GG G C C G C | 0.008 0.025 0.001 0.034 0.02952 0.001 | China China Iran Iran Iran Saudi Arabia | Dai et al. 2016 [57] Hu et al. 2009 [59] Omrani et al. 2014 [70] Afsharzadeh et al., 2017 [77] Kabirizadeh et al., 2016 [79] Alshtawi et al. 2012 [87] | |
218-2 | rs11134527:A > G | G | < 0.0001 | Iran | Danesh et al. 2018 [74] | |
301-b | rs384262G > A | A | < 0.0001 | Iran | Danesh et al. 2018 [74] | |
605 | rs2043556T:A > G | G | 0.00003 | Iran | Kazemi et al. 2020 [75] | |
599 | rs58450758:C > T | CT and TT | < 0.0001 | Iran | Bahreini et al. 2019 [81] | |
423 | rs6505162:C > A | A T | 0.02 0.0001 | Chile Saudi Arabia | Morales et al. 2016 [106] MiR et al. 2018 [88] | |
513a-2 | rs2018562:A > G | G | 0.03 | USA | Yao et al. 2013 [101] | |
106b | rs1527423:A > G | G | 0.02 | USA | Yao et al. 2013 [101] | |
182 | rs4541843:C > T | T | 0.01 | Chile | Morales et al. 2018 [107] | |
101-2 | rs462480:A > C rs105387:C > G | C G | 0.017 0.010 | China | Chen et al. 2014 [65] | |
Let-7 | rs13293512:T > C | C | 0.013 | China | Sun et al., 2019 [64] | |
331 | rs1110793:A > G | G | 0.02 | USA | Yao et al. 2013 [101] | |
544 | rs10144193:A > T | T | 0.004 | USA | Yao et al. 2013 [101] | |
487 | rs1951032G > A | A | 0.001 | USA | Yao et al. 2013 [101] | |
659 | rs5750504:T > A | A | 0.03 | USA | Yao et al. 2013 [101] | |
618 | rs2682818C > A | CA | 0.03 | Chile | Morales et al. 2016 [106] | |
Decreased risk | 27a | rs895819:A > G or T > C | GG G G G G T | 0.01 0.032 0.0287 < 0.001 0.001 0.013 | Chile China Germany Iran Iran Israel | Morales et al. 2016 [106] Zhang et al. 2013 [58] Yang et al. 2010 [93] Mashayekhi et al. 2018 [69] Parchami Barjui et al. 2017 [76] Kontorovich et al. 2010 [86] |
499 | rs3746444:T > C | C | 0.003 | Iran | Doulah et al. 2018 [71] | |
608 | rs4919510:C > G | G | 0.024 | Iran | Hashemi et al. 2016 [80] | |
520f | rs75598818:G > A | GA | 0.041 | Iran | Meshkat et al. 2018 [82] | |
196a2 | rs11614913:C > T | CC T T T | 0.009 0.0005 0.002 0.00295 | Brazil China USA Vietnam | Linhares et al. 2012 [108] Dai et al. 2016 [57] Hoffman et al. 2009 [100] Mihn et al. 2018 [90] | |
758 | rs12586258:G > A | A | 0.01 | USA | Yao et al. 2013 [101] | |
100 | rs1834306:G > A | A | 0.02 | USA | Yao et al. 2013 [101] | |
185 | rs2008595:C > T rs887205:A > G | TT GG | 0.04 0.03 | USA | Bensen et al. 2013 [102] | |
423 | rs6505162:A > C | CC | 0.035 | Australia | Smith et al. 2012 [104] | |
605 | rs2043556:T > C | C | 0.02 | Chile | Morales et al. 2018 [107] | |
146a | rs2910164:G > C | C | 0.01 | India | Bansal et al. 2014 [67] | |
149 | rs2292832:T > C | CC | 0.053 | China | He et al. 2015 [56] | |
30a | rs763354:G > A | A | 0.022 | China | Zhou et al. 2020 [66] |