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  1. The internal NAD(P)H dehydrogenase (NDA) gene family was a member of the NAD(P)H dehydrogenase (ND) gene family, mainly involved in the non-phosphorylated respiratory pathways in mitochondria and played crucia...

    Authors: Yapeng Fan, Yuexin Zhang, Cun Rui, Hong Zhang, Nan Xu, Jing Wang, Mingge Han, Xuke Lu, Xiugui Chen, Delong Wang, Shuai Wang, Lixue Guo, Lanjie Zhao, Hui Huang, Junjuan Wang, Liangqing Sun…

    Citation: Biological Research 2022 55:4

    Content type: Research article

    Published on:

  2. Authors: Karla G. Schwarz, Katherin V. Pereyra, Camilo Toledo, David C. Andrade, Hugo S. Díaz, Esteban Díaz-Jara, Domiziana Ortolani, Angélica Rios-Gallardo, Paulina Arias, Alexandra Las Heras, Ignacio Vera, Fernando C. Ortiz, Nibaldo C. Inestrosa, Carlos P. Vio and Rodrigo Del Rio

    Citation: Biological Research 2022 55:3

    Content type: Correction

    Published on:

    The original article was published in Biological Research 2021 54:43

  3. Chinese hamster ovary cell line has been used routinely as a bioproduction factory of numerous biopharmaceuticals. So far, various engineering strategies have been recruited to improve the production efficienc...

    Authors: Fatemeh Safari and Bahman Akbari

    Citation: Biological Research 2022 55:2

    Content type: Research article

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  4. Maize (Zea mays L.) is a widely cultivated cereal and has been used as an optimum heavy metal phytoremediation crop. Metallothionein (MT) proteins are small, cysteine-rich, proteins that play important roles in p...

    Authors: Canhong Gao, Kun Gao, Huixian Yang, Tangdan Ju, Jingyi Zhu, Zailin Tang, Liangxia Zhao and Qingquan Chen

    Citation: Biological Research 2022 55:1

    Content type: Research article

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  5. Entomopathogenic fungi (EPF) are the natural enemies of insect pests. Nevertheless, research on the use of EPF for simultaneous prevention of pest and disease agents on the same crop is limited. In this study,...

    Authors: Juan Aguilera-Sammaritano, Juan Caballero, María Deymié, Melisa Rosa, Fabio Vazquez, Delia Pappano, Bernardo Lechner and Marcia González-Teuber

    Citation: Biological Research 2021 54:44

    Content type: Research article

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  6. Chronic heart failure (CHF) is a global health problem. Increased sympathetic outflow, cardiac arrhythmogenesis and irregular breathing patterns have all been associated with poor outcomes in CHF. Several stud...

    Authors: Karla G. Schwarz, Katherin V. Pereyra, Camilo Toledo, David C. Andrade, Hugo S. Díaz, Esteban Díaz-Jara, Domiziana Ortolani, Angélica Rios-Gallardo, Paulina Arias, Alexandra Las Heras, Ignacio Vera, Fernando C. Ortiz, Nibaldo C. Inestrosa, Carlos P. Vio and Rodrigo Del Rio

    Citation: Biological Research 2021 54:43

    Content type: Research article

    Published on:

    The Correction to this article has been published in Biological Research 2022 55:3

  7. Diosmetin is a bioflavonoid compound naturally abundant in citrus fruits. It is found to perform a variety of activities, while its antitumor property in osteosarcoma, a malignant tumor with unmet clinical tre...

    Authors: Rende Ning, Guang Chen, Run Fang, Yanhui Zhang, Wenjuan Zhao and Feng Qian

    Citation: Biological Research 2021 54:40

    Content type: Research article

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  8. The aim of the study was to investigate the effect of mild cerebral hypoxia on haemoglobin oxygenation (HbO2), cerebrospinal fluid dynamics and cardiovascular physiology. To achieve this goal, four signals were r...

    Authors: Agnieszka Gruszecka, Monika Waskow, Marta A. Malkiewicz, J. Patrick Neary, Jyotpal Singh, Taylor Teckchandani, Gregory P. Kratzig, Magdalena Wszedybyl-Winklewska, Andrzej F. Frydrychowski, Jacek Rumiński, Natalia Głowacka, Piotr Lass, Pawel J. Winklewski and Marcin Gruszecki

    Citation: Biological Research 2021 54:39

    Content type: Research article

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  9. Defective chloride transport in airway epithelial cells (AECs) and the associated lung disease are the main causes of morbidity and early mortality in cystic fibrosis (CF). Abnormal airway iron homeostasis and...

    Authors: Pramila Maniam, Ama-Tawiah Essilfie, Murugan Kalimutho, Dora Ling, David M. Frazer, Simon Phipps, Gregory J. Anderson and David W. Reid

    Citation: Biological Research 2021 54:38

    Content type: Research article

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  10. Breast cancer is the most frequently diagnosed cancer, and no effective treatment solution has yet been found. The number of studies based on the research of novel natural compounds in the treatment of breast ...

    Authors: Demet Cansaran-Duman, Sevcan Yangın and Betül Çolak

    Citation: Biological Research 2021 54:37

    Content type: Research article

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  11. Melatonin 2-hydroxylase (M2H) is the first enzyme in the catabolism pathway of melatonin, which catalyzes the production of 2-hydroxymelatonin (2-OHM) from melatonin. The content of 2-hydroxymelatonin in plant...

    Authors: Yuexin Zhang, Jing Wang, Xiugui Chen, Xuke Lu, Delong Wang, Junjuan Wang, Shuai Wang, Chao Chen, Lixue Guo, Waqar Afzal Malik, Yapeng Fan, Cun Rui, Ruifeng Cui, Qinqin Wang, Yuqian Lei and Wuwei Ye

    Citation: Biological Research 2021 54:36

    Content type: Research article

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  12. Urushiols are pro-electrophilic haptens that cause severe contact dermatitis mediated by CD8+ effector T-cells and downregulated by CD4+ T-cells. However, the molecular mechanism by which urushiols stimulate inna...

    Authors: Rodrigo Pacheco, Sergio A. Quezada, Alexis M. Kalergis, María Inés Becker, Jorge Ferreira and Alfredo E. De Ioannes

    Citation: Biological Research 2021 54:35

    Content type: Research article

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  13. Xanthophyllomyces dendrorhous is a basidiomycete yeast that naturally produces the red–orange carotenoid astaxanthin, which has remarkable antioxidant properties. The biosynthesis of carotenoids and sterols share...

    Authors: Melissa Gómez, Marcelo Baeza, Víctor Cifuentes and Jennifer Alcaíno

    Citation: Biological Research 2021 54:34

    Content type: Review

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  14. The antisense noncoding mitochondrial RNAs (ASncmtRNAs) derive from the mitochondrial 16S gene. Knockdown of these transcripts with chemically-modified antisense oligonucleotides induces proliferative arrest, ...

    Authors: Nicole Farfán, Nicole Sanhueza, Macarena Briones, Luis O. Burzio and Verónica A. Burzio

    Citation: Biological Research 2021 54:33

    Content type: Short report

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  15. Deep breathing (DB) and handgrip (HG) exercise -with and without circulatory occlusion (OC) in muscle-, have been shown to have beneficial effects on cardiovascular function; however, the combination of these ...

    Authors: David C. Andrade, Claudia Melipillan, Camilo Toledo, Angélica Rios-Gallardo, Noah J. Marcus, Fernando C. Ortiz, Gonzalo Martinez, Paula Muñoz Venturelli and Rodrigo Del Rio

    Citation: Biological Research 2021 54:32

    Content type: Research article

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  16. Heart failure (HF) is the leading cause of death in western countries. Cardiac dysfunction is accompanied by skeletal alterations resulting in muscle weakness and fatigue. Exercise is an accepted interventiona...

    Authors: Julia Böttner, Sarah Werner, Volker Adams, Sarah Knauth, Angela Kricke, Holger Thiele and Petra Büttner

    Citation: Biological Research 2021 54:31

    Content type: Research article

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  17. This study aims to identify the effect of miR-146a-5p on trophoblast cell invasion as well as the mechanism in preeclampsia (PE).

    Authors: Pingping Peng, Huamei Song, Chenghong Xie, Wenfei Zheng, Huigai Ma, Dandan Xin, Jingqiong Zhan, Xiaoqing Yuan, Aihua Chen, Jing Tao and Jufang Qin

    Citation: Biological Research 2021 54:30

    Content type: Research article

    Published on:

  18. Improving the nutritional condition of grapevine in spring to regulate bloom, fruit set, and yield is among the management goals of vineyards.

    Authors: Rouhollah Karimi, Abbas Saberi and Ali Khadivi

    Citation: Biological Research 2021 54:28

    Content type: Research article

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  19. Demethylzeylasteral (T-96) is a pharmacologically active triterpenoid monomer extracted from Tripterygium wilfordii Hook F (TWHF) that has been reported to exhibit anti-neoplastic effects against several types of...

    Authors: Dong-lin Yang, Ya-jun Zhang, Liu-jun He, Chun-sheng Hu, Li-xia Gao, Jiu-hong Huang, Yan Tang, Jie Luo, Dian-yong Tang and Zhong-zhu Chen

    Citation: Biological Research 2021 54:27

    Content type: Research article

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  20. Breast cancer (BC), a heterogeneous, aggressive illness with high mortality, is essentially a genomic disease. While the high-penetrance genes BRCA1 and BRCA2 play important roles in tumorigenesis, moderate- and ...

    Authors: Trinidad Arancibia, Sebastian Morales-Pison, Edio Maldonado and Lilian Jara

    Citation: Biological Research 2021 54:26

    Content type: Review

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  21. Peroxisome proliferator-activated receptor alpha (PPARα) is associated with diabetic retinopathy (DR), and the underlying mechanism is still unclear. Aim of this work was to investigate the mechanism of PPARα ...

    Authors: Ying Zhu, Xinru Wang, Xiaoyun Zhou, Lexi Ding, Dan Liu and Huizhuo Xu

    Citation: Biological Research 2021 54:25

    Content type: Research article

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  22. Accumulating evidence has demonstrated that the electroacupuncture (EA) stimulation could effectively alleviate neuropathic pain. The medial prefrontal cortex (mPFC) is a vital part of the cortical representat...

    Authors: Menghong Jiang, Xiaomei Chen, Liangping Zhang, Weiting Liu, Xiangmei Yu, Zhifu Wang and Meifeng Zheng

    Citation: Biological Research 2021 54:24

    Content type: Review

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  23. The Ras family of small Guanosine Triphosphate (GTP)-binding proteins (G proteins) represents one of the main components of intracellular signal transduction required for normal cardiac growth, but is also cri...

    Authors: Manuel Ramos-Kuri, Sri Harika Meka, Fabio Salamanca-Buentello, Roger J. Hajjar, Larissa Lipskaia and Elie R. Chemaly

    Citation: Biological Research 2021 54:23

    Content type: Review

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  24. Accumulated evidence demonstrates cisplatin, a recommended chemotherapy, modulating pro-survival autophagic response that contributes to treatment failure in lung cancer patients. However, distinct mechanisms ...

    Authors: Somruethai Sumkhemthong, Eakachai Prompetchara, Pithi Chanvorachote and Chatchai Chaotham

    Citation: Biological Research 2021 54:22

    Content type: Research article

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  25. Chagas disease is considered important and presents intense inflammatory and fibrotic processes induced by the perpetuation of the parasite in the affected tissues and organs. Therefore, it is necessary to inq...

    Authors: Martha Alicia Ballinas-Verdugo, Rogelio Frank Jiménez-Ortega, Eduardo Martínez-Martínez, Nancy Rivas, Erick Abraham Contreras-López, Roxana Carbó, Fausto Sánchez, Rafael Bojalil, Ricardo Márquez-Velasco, Fausto Sánchez-Muñoz and Ricardo Alejandre-Aguilar

    Citation: Biological Research 2021 54:21

    Content type: Research article

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  26. The current COVID-19 pandemic has already claimed more than 3.7 million victims and it will cause more deaths in the coming months. Tools that track the number and locations of cases are critical for surveilla...

    Authors: Raúl Arias-Carrasco, Jeevan Giddaluru, Lucas E. Cardozo, Felipe Martins, Vinicius Maracaja-Coutinho and Helder I. Nakaya

    Citation: Biological Research 2021 54:20

    Content type: Letter to the Editor

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  27. In the era of climate change, due to increased incidences of a wide range of various environmental stresses, especially biotic and abiotic stresses around the globe, the performance of plants can be affected b...

    Authors: Xiu-Peng Song, Krishan K. Verma, Dan-Dan Tian, Xiao-Qiu Zhang, Yong-Jian Liang, Xing Huang, Chang-Ning Li and Yang-Rui Li

    Citation: Biological Research 2021 54:19

    Content type: Review

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  28. The MVD gene mutations are identified in porokeratosis, which is considered a skin-specific autoinflammatory keratinization disease. However, the biological function of MVD gene remains largely unknown. Therefore...

    Authors: Wenghong Wong, Yike Huang, Zhuanbin Wu, Yu Kong, Jing Luan, Qiaoan Zhang, Jiewen Pan, Kexiang Yan and Zhenghua Zhang

    Citation: Biological Research 2021 54:17

    Content type: Research article

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  29. Recently, there is increasing awareness focused on the identification of naturally occurring anticancer agents derived from natural products. Manuka honey (MH) has been recognized for its biological properties...

    Authors: Heba R. Al Refaey, Al-Sayeda A. Newairy, Mayssaa M. Wahby, Chris Albanese, Mohamed Elkewedi, Muhammad Umer Choudhry and Ahmed S. Sultan

    Citation: Biological Research 2021 54:16

    Content type: Research article

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  30. Water stress is one of the serious abiotic stresses that negatively influences the growth, development and production of sugarcane in arid and semi-arid regions. However, silicon (Si) has been applied as an al...

    Authors: Krishan K. Verma, Xiu-Peng Song, Chhedi Lal Verma, Zhong-Liang Chen, Vishnu D. Rajput, Kai-Chao Wu, Fen Liao, Gan-Lin Chen and Yang-Rui Li

    Citation: Biological Research 2021 54:15

    Content type: Research article

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  31. Circular RNAs (circRNAs) has emerged as vital regulator involved in various diseases. In this study, we identified and investigated the potential circRNAs involved in gestational diabetes mellitus (GDM).

    Authors: Haitian Chen, Shaofeng Zhang, Yanxin Wu, Zhuyu Li, Dongyu Wang, Shiqin Cai and Zilian Wang

    Citation: Biological Research 2021 54:14

    Content type: Research article

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  32. Helicobacter pylori is detected by pathogen recognition receptors including toll-like receptors (TLR) and nucleotide-binding oligomerization domain (NOD)-like receptors, eliciting an innate immune response agains...

    Authors: Patricio Gonzalez-Hormazabal, Diana Pelaez, Maher Musleh, Marco Bustamante, Juan Stambuk, Raul Pisano, Hector Valladares, Enrique Lanzarini, Hector Chiong, Jose Suazo, Luis A. Quiñones, Nelson M. Varela, V. Gonzalo Castro, Lilian Jara and Zoltan Berger

    Citation: Biological Research 2021 54:13

    Content type: Research article

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  33. Multiple sclerosis (MS) is a central nervous system disease with a high disability rate. Modern molecular biology techniques have identified a number of key genes and diagnostic markers to MS, but the etiology...

    Authors: Xin Chen, Huiqing Hou, Huimin Qiao, Haolong Fan, Tianyi Zhao and Mei Dong

    Citation: Biological Research 2021 54:12

    Content type: Research article

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  34. Atherosclerosis (AS) is the most common type in cardiovascular disease. Due to its complex pathogenesis, the exact etiology of AS is unclear. circRNA has been shown to play an essential role in most diseases. ...

    Authors: Xiaohao Zhang, Junying Lu, Qinghua Zhang, Qiang Luo and Bin Liu

    Citation: Biological Research 2021 54:11

    Content type: Research article

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  35. Parkinson’s disease (PD) is a common age-related neurodegenerative disorder worldwide. This research aimed to investigate the effects and mechanism underlying long non-coding RNA metastasis-associated lung ade...

    Authors: Kefeng Lv, Yuhua Liu, Yanbing Zheng, Shaowen Dai, Peifeng Yin and Haifeng Miao

    Citation: Biological Research 2021 54:10

    Content type: Research article

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  36. PGF2α is essential for the induction of the corpus luteum regression which in turn reduces progesterone production. Early growth response (EGR) proteins are Cys2-His2-type zinc-finger transcription factor that...

    Authors: Meeti Punetha, Sai Kumar, Avishek Paul, Bosco Jose, Jaya Bharati, Arvind Sonwane, Jonathan A. Green, Kristin Whitworth and Mihir Sarkar

    Citation: Biological Research 2021 54:9

    Content type: Research article

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  37. This study aimed to investigate the potential role and molecular mechanism of lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in cerebral ischemia/reperfusion injury.

    Authors: Ying Jia, Lian Yi, Qianqian Li, Tingjiao Liu and Shanshan Yang

    Citation: Biological Research 2021 54:8

    Content type: Research article

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  38. Mitochondria play a significant role in plant cytoplasmic male sterility (CMS). In our previous study, mitochondrial complex I genes, nad4, nad5, and nad7 showed polymorphisms between the transgenic CMS line M2BS...

    Authors: Danfeng Tang, Fan Wei, Aziz Khan, Fazal Munsif and Ruiyang Zhou

    Citation: Biological Research 2021 54:6

    Content type: Research article

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  39. Early-life stress in the form of maternal separation can be associated with alterations in offspring neurodevelopment and brain functioning. Here, we aimed to investigate the potential impact of prolonged mate...

    Authors: Zdenka Drastichova, Vladimir Rudajev, Gergely Pallag and Jiri Novotny

    Citation: Biological Research 2021 54:4

    Content type: Research article

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  40. Testosterone regulates nutrient and energy balance to maintain protein synthesis and metabolism in cardiomyocytes, but supraphysiological concentrations induce cardiac hypertrophy. Previously, we determined th...

    Authors: Mayarling Francisca Troncoso, Mario Pavez, Carlos Wilson, Daniel Lagos, Javier Duran, Sebastián Ramos, Genaro Barrientos, Patricio Silva, Paola Llanos, Carla Basualto-Alarcón, B. Daan Westenbrink, Sergio Lavandero and Manuel Estrada

    Citation: Biological Research 2021 54:3

    Content type: Research article

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  41. The preventive and therapeutic medical utilization of this plant is an age-long practice across the globe. This study aimed to validate the impact of dark purple blossoms of basil (Ocimum basilicum L.) aqueous ex...

    Authors: Mariam Abdulaziz Alkhateeb, Wedad Refaiea Al-Otaibi, Qwait AlGabbani, Amena Ali Alsakran, Alaa Ahmed Alnafjan, Amani Mohammed Alotaibi and Wedad Saeed Al-Qahtani

    Citation: Biological Research 2021 54:2

    Content type: Research article

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  42. Neuronal apoptosis plays a critical event in the pathogenesis of early brain injury after subarachnoid hemorrhage (SAH). This study investigated the roles of Tauroursodeoxycholic acid (TUDCA) in attenuate neur...

    Authors: Huihui Wu, Nini Yu, Xia Wang, Yina Yang and Hui Liang

    Citation: Biological Research 2020 53:56

    Content type: Research article

    Published on:

  43. UV-B signaling in plants is mediated by UVR8, which interacts with transcriptional factors to induce root morphogenesis. However, research on the downstream molecules of UVR8 signaling in roots is still scarce...

    Authors: Meiting Du, Yanhong Wang, Huize Chen and Rong Han

    Citation: Biological Research 2020 53:54

    Content type: Research article

    Published on: