%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
2020-04-17T13:36:06+05:30
Springer
2020-04-20T17:32:49+02:00
2020-04-20T17:32:49+02:00
Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
Ischemic stroke,Ischemia/reperfusion injury,miR-19a-3p,IGFBP3
application/pdf
https://doi.org/10.1186/s40659-020-00280-9
BioMed Central
Biological Research, https://doi.org/10.1186/s40659-020-00280-9
Ischemic stroke
Ischemia/reperfusion injury
miR-19a-3p
IGFBP3
Inhibition of miR-19a-3p decreases cerebral ischemia/reperfusion injury by targeting IGFBP3 in vivo and in vitro
Zhaohui Chai
Jiangbiao Gong
Peidong Zheng
Jiesheng Zheng
10.1186/s40659-020-00280-9
2010-04-23
true
springer.com
springerlink.com
https://doi.org/10.1186/s40659-020-00280-9
10.1186/s40659-020-00280-9
0717-6287
journal
Biological Research
The Author(s)
2010-04-23
true
10.1186/s40659-020-00280-9
noindex
springer.com
springerlink.com
VoR
uuid:541a34e5-9d72-4018-aa90-5b4de7d673b2
uuid:9c649111-c065-4882-b498-967dd5150f0b
default
1
converted
uuid:0a60ae8b-443e-4559-8cf7-f44c9fc6edea
converted to PDF/A-2b
pdfToolbox
2020-04-17T13:37:20+05:30
2
B
http://ns.adobe.com/pdfx/1.3/
pdfx
Adobe Document Info PDF eXtension Schema
external
Mirrors crossmark:MajorVersionDate
CrossmarkMajorVersionDate
Text
external
Mirrors crossmark:CrossmarkDomainExclusive
CrossmarkDomainExclusive
Text
internal
Mirrors crossmark:DOI
doi
Text
external
Mirrors crossmark:CrosMarkDomains
CrossMarkDomains
seq Text
internal
A name object indicating whether the document has been modified to include trapping information
robots
Text
internal
ID of PDF/X standard
GTS_PDFXVersion
Text
internal
Conformance level of PDF/X standard
GTS_PDFXConformance
Text
internal
Company creating the PDF
Company
Text
internal
Date when document was last modified
SourceModified
Text
http://crossref.org/crossmark/1.0/
crossmark
Crossmark Schema
internal
Usual same as prism:doi
DOI
Text
external
The date when a publication was publishe.
MajorVersionDate
Text
internal
CrossmarkDomainExclusive
CrossmarkDomainExclusive
Text
internal
CrossMarkDomains
CrossMarkDomains
seq Text
http://prismstandard.org/namespaces/basic/2.0/
prism
Prism Schema
external
This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.
url
URI
external
The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL).
doi
Text
external
ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.
issn
Text
internal
Volume number
volume
Text
internal
Issue number
number
Text
internal
Starting page
startingPage
Text
internal
Ending page
endingPage
Text
external
The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary.
aggregationType
Text
external
Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”
publicationName
Text
external
Copyright
copyright
Text
http://ns.adobe.com/pdf/1.3/
pdf
Adobe PDF Schema
internal
A name object indicating whether the document has been modified to include trapping information
Trapped
Text
http://ns.adobe.com/xap/1.0/mm/
xmpMM
XMP Media Management Schema
internal
UUID based identifier for specific incarnation of a document
InstanceID
URI
internal
The common identifier for all versions and renditions of a document.
DocumentID
URI
internal
The common identifier for all versions and renditions of a document.
OriginalDocumentID
URI
internal
A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.
DerivedFrom
ResourceRef
Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.
http://ns.adobe.com/xap/1.0/sType/Part#
stPart
Part
http://www.aiim.org/pdfa/ns/id/
pdfaid
PDF/A ID Schema
internal
Part of PDF/A standard
part
Integer
internal
Amendment of PDF/A standard
amd
Text
internal
Conformance level of PDF/A standard
conformance
Text
http://www.niso.org/schemas/jav/1.0/
jav
NISO
external
Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record
journal_article_version
Closed Choice of Text
endstream
endobj
3 0 obj
<>
endobj
7 0 obj
[9 0 R 10 0 R 11 0 R 12 0 R 13 0 R 14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R]
endobj
9 0 obj
<>/Subtype/Link/Dest(40659_2020_280_Article.indd:CR3:75)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[260.196 692.391 265.115 680.224]>>
endobj
10 0 obj
<>/Subtype/Link/Dest(40659_2020_280_Article.indd:CR6:78)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[271.044 692.391 275.964 680.224]>>
endobj
11 0 obj
<>/Subtype/Link/Dest(40659_2020_280_Article.indd:CR7:79)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[187.477 632.391 192.397 620.224]>>
endobj
12 0 obj
<>/Subtype/Link/Dest(40659_2020_280_Article.indd:CR9:81)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[198.325 632.391 203.245 620.224]>>
endobj
13 0 obj
<>/Subtype/Link/Dest(40659_2020_280_Article.indd:CR10:82)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[143.293 572.391 153.132 560.224]>>
endobj
14 0 obj
<>/Subtype/Link/Dest(40659_2020_280_Article.indd:CR11:83)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[179.135 548.391 188.974 536.224]>>
endobj
15 0 obj
<>/Subtype/Link/Dest(40659_2020_280_Article.indd:CR12:84)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[94.0226 512.391 103.862 500.224]>>
endobj
16 0 obj
<>/Subtype/Link/Dest(40659_2020_280_Article.indd:CR13:85)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[181.222 452.391 191.061 440.224]>>
endobj
17 0 obj
<>/Subtype/Link/Dest(40659_2020_280_Article.indd:CR14:86)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[195.418 440.391 205.257 428.224]>>
endobj
18 0 obj
<>/Subtype/Link/Dest(40659_2020_280_Article.indd:CR15:87)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[103.906 428.391 113.745 416.224]>>
endobj
19 0 obj
<>/Subtype/Link/Dest(40659_2020_280_Article.indd:CR16:88)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[85.503 392.391 95.3422 380.224]>>
endobj
20 0 obj
<>/Subtype/Link/Dest(40659_2020_280_Article.indd:CR17:89)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[261.476 332.391 271.315 320.224]>>
endobj
21 0 obj
<>/Subtype/Link/Dest(40659_2020_280_Article.indd:CR18:90)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[211.809 284.391 221.648 272.224]>>
endobj
22 0 obj
<>/Subtype/Link/Dest(40659_2020_280_Article.indd:CR19:91)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[235.367 272.391 245.206 260.224]>>
endobj
23 0 obj
<>/Subtype/Link/Dest(40659_2020_280_Article.indd:CR20:92)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[92.3454 260.391 102.185 248.224]>>
endobj
24 0 obj
<>/Subtype/Link/Dest(40659_2020_280_Article.indd:CR21:93)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[104.85 248.391 114.69 236.224]>>
endobj
25 0 obj
<>/Subtype/Link/Dest(40659_2020_280_Article.indd:CR22:94)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[59.8876 188.391 69.7268 176.224]>>
endobj
26 0 obj
<>/Subtype/Link/Dest(40659_2020_280_Article.indd:CR23:95)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[127.05 188.391 136.889 176.224]>>
endobj
27 0 obj
<>/Subtype/Link/Dest(40659_2020_280_Article.indd:CR24:96)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[206.266 188.391 216.105 176.224]>>
endobj
28 0 obj
<>/Subtype/Link/Dest(40659_2020_280_Article.indd:CR25:97)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[354.218 259.391 364.057 247.224]>>
endobj
6 0 obj
<>/ProcSet[/PDF/Text]/Font<>/XObject<>>>
endobj
4 0 obj
<>stream
x\rV}R7u'00(dE,-vQ~XDӡ4 d6 !}fж+2Gwn,/]Yv?H9k1$7'NVuz䄟=З[nZlI @"h6m"T#'z)R#wC- _AP ;X]`ڊgV1["*Pm 4x@Bje,ќx\$I6C[W/:>xVҪV={_@H>g-b3Iט Ocӻق`Lѕ#7P&$Uxr98_= w+
W r~T$c{1 t~8-끥/!%eZKeh{ x =Oi8{4F7x
[+=O
p:lȞ䔒XnfV4{>X"?~) paoĽnM\Jmk66s}IXhAx=?!ND".pcu|%G:nPlx}Z&RiZh-n@C&aY1l& ک4zy]/6yEx
`? \K"!/Ǎ vǛ2͵ywp"'z9zAs/p.zgp(|h>>~$f#F}>Id#ܳ 3ѓ8Us_c+Sr}UڿjYFIkb(OBgPQB:bٸ)'~ց%&ZH ҙ5s@3Q8R1Rb<(BX]QZBjCR?4NIIJ0- ;.O{Sh2tdK4!^+ZN8tie=wU@YMp#IjnWWSմb"nֵ|ym|@OɴDX*=~Y,?}l,Ѽ#:#q@Sw:*yy]83rza
nt
2kڅƨJ[15xx2,E<mK DE4뢥g9r
$lL1J!´&J,c; 5FzՀ*u֪YxT@=
ŚG3w2J
q$3b"jiNY0BEM_>beS!] ao6[Ǽ)&wL;J VbKa~$岬X6YdKYa4\NH3o<#$+kxV՜M|茎'8ސP
s9bh_m3,]Sc)H߽RǝS4F(.0=|<#H@]Y\LMO.~_g'//1?GqRV
cNӧuB]9}
t#@uJز>'W»5ol X7}Z[rop>hf{=B*~;6`ԉHLj4Z.Sh$jw8:E9i/<_,5~$n8kh# ayK毅FFHϰALn'[6n+Hb~OHdW
710H)`-r+17* k-eKG.4Ifzܺ斟,nm^T=-TGjS?RHTNkq_N%Ŗ֓F"-\q]/d\+4
XTPk%w kBJAϡڢcS$kbએblHkzh)f^rtz%AG41k*Ft"'^cGSrȷEuמ.x%K;~Lll.\|
uA%Pj]ݾ*kgL ;Ř]rDiN!wzpr,Mby 5BUkv)zd
>F
CaUIMp#fF=J8(T"f3aEsd3U6U{OajhD(XRq`91cxr|D}ܪ/:fārh;4cڕ0/h`X$0E,4]m 'T)q(t*"?_£!Y
ᩯ DY!
h`@zL[a?acУz?9-ᓿ5Uw#E C@XiͶO83QEX$_B r9WEi Y$+x5\TpFWx!EƋ=G̏pu8pk]!.X㗕l
`x]Ӱ(xiYZ
|FMDJ_ =41}4ȵg/=D[^J뙯^-icυE$Olũ4gq4B^<^/@E/7$oio
Pj|'<GDrC99iNmvsҞS;LMIXCw龰$v
%XөΙZT*t*,
2Lk[0jL|:ʆ>p.=ƊaT au@W|hIZzy
y
f3I7I18ċv¹I1A2
1uhTo׳opH,ͪ\xi@?> E?A4#yNHm\7ZsePUl)~p)C6z | &$0Fwu"Ev
<ў֙w}*'<-}:E '>!'\ͲY&PNotxZi
JIHIJ
&Ng)QHhk8A.BŢ$,u>1ud2bǕ:w5\ZU}}lpĞ
;G!/p(]3XA[=zÑ1mIA,UIF9vF~rNҤ[oNWՏU)U9 J\}/z\!0*su)u>m-ЯdS[BR>Ɋ$UNF/%ۿPVkikjc@
/
Yr]K!؟q8(RԲarrUTț)~o22?0G+̧'d+Ȇ楓?Koa#n.˛no귳陠~9zX( Oo.0Og1ܸ%HhOf"H* Ҍ/+r9zzfd~]Os:uX)IC~Q`EסڼH0r8B;5U^]e`s@%/jY*POxLFАqq|hj̯:_AYQ'so
3 \$P #'#tU9~UB5Iξwp`M&aC}"njm>?
NO
.Ӌ TYxX82pNdD;8ˀfprK@dgSi^4F1, l*A=9CN-|(C=\a)Ox3/㡶nƍ\+"Qk z0*s:י9@`Z{k+ͥh/4;W;.c^FIw[nx!:6nc _J;Х0(F*r1Lz==ɂwf Ki̍o=#@
-1ڦM~Cַ#<[xz#Q%0s<ǡBxh::wqG#iuSuơrsU#pKcgd6>7rq:k3Zߴ<2Kjp Ժtc^8X8DA
6_ ~j/4䇃m1D"G&ܛzǦ51ݺf'̼Z 2Iٔ
pn[ 0tR(x!jS>h^l\|D~X.\fɴ;pt{'eu`) q#)=H)$L\`K0` sec;E`Sgdڗ]cr/iۘumB=r>>lԪ4݁bq6|n
yˇ=[`w|RݿGrpy`Eۏ͝zv4o6^Vr6};㬇\>t:<t
刷̱sCvCh{?q{Oz|O nlUboIhf]|f^@`Д[pc`>z{%?
endstream
endobj
49 0 obj
<>
endobj
53 0 obj
[54 0 R 55 0 R]
endobj
54 0 obj
<>/Subtype/Link/Dest(40659_2020_280_Article.indd:CR26:98)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[216.681 522.656 226.521 510.489]>>
endobj
55 0 obj
<>/Subtype/Link/Dest(40659_2020_280_Article.indd:CR27:99)/F 4/Type/Annot/H/N/Border[0 0 0]/AP<>/Rect[84.2996 510.656 94.1387 498.489]>>
endobj
52 0 obj
<>/ProcSet[/PDF/Text]/Font<>/XObject<>>>
endobj
50 0 obj
<>stream
x\rFvo@-W)F*lz%YMĭԐi`a0\$ӏHU09 f(ܭeYfr.dR}ww냣s)AIJUe\"/+ORgToWȣ黚I|8z_pUѳEʞ,u*OJT紩Rgt26_?y>|=mc%qlz?HEz3%z*S1syYLRq-"q!SXE3ZyOvOT>
?>mA/ҼϦ
}u^k$UR6p'p*.#v+
|k$jeӎ]뷇3+ۚm