Fig. 1

Assessment of ADAR activity in BC cell lines. a Correlation between A and G(I) variants and ADAR isoforms (RPKM) for the 81 breast cells lines included in the PRJNA297219 dataset. Linear regression for normalized data, Spearman Correlation r = 0.585, p < 0.0001 (ADAR1); r = 0.476, p < 0.0001 (ADAR2), r = 0.07, p < 0.499 (ADAR3) and r = 0.697, p < 0.0001(ADAR1 CCLE CNV). b Reactome pathway enrichment associated with A to G(I) variants present in 10% of the BC cell lines. c Variant distribution of edited sites for variants present on breast cell lines. d Variant counts present in non-malignant MCF10A, MCF12A and 184A1 cell lines and BC cells, according the different transcript regions. e Variant counts significantly edited in BC cells distributed according genomic regions, compared to immortalized non-malignant MCF10A, MCF12A and 184A1 cell lines. d*: Kolmogorov–Smirnov p < 0.05, ns non-significant differences