Fig. 1
From: Berberine in combination with cisplatin induces necroptosis and apoptosis in ovarian cancer cells
BBR inhibited cell proliferation and enhanced the inhibitory effect of DDP when they were used in combination. OVCAR3 cells (a) and POCCLs (b) were exposed to various concentrations of BBR for the indicated periods. *p < 0.05, **p < 0.01 compared with the respective 24 h, 48 h and 72 h controls. The inhibitory effect of BBR (100 μM) in combination with DDP (5 mg/L) on OVCAR cells (c) and POCCLs (d) after 24-h treatment. Cell viability was measured by CCK-8 assay. *p < 0.05, **p < 0.01 compared with DDP group. #p < 0.05, ##p < 0.01 compared with BBR group. Data were based on at least three independent experiments, and shown as mean ± SD