From: The roles of miRNA, lncRNA and circRNA in the development of osteoporosis
miRNA ID | Target molecule and pathway | Mechanisms that affect osteoporosis through osteoblasts and osteoclasts |
---|---|---|
miR-33-5p [20] | Hmga2 | Promote osteoblast differentiation |
miR-194 [22] | Runx2 | Promote osteoblast differentiation |
miRNA-433-3p [23] | DKK1 | Promote osteoblast differentiation |
EGFR, HB-EGF | Promote osteoblast differentiation Promote osteoblast differentiation | |
Wnt/β-catenin signaling pathway | ||
miR-139-5p [27] | NOTCH1,Wnt/β-catenin pathway | Promote osteoblast differentiation |
miR-216a [28] | PI3K/AKT pathway | Promote osteoblast differentiation Promote osteoblast differentiation |
BMP/TGF-β signaling pathway, | ||
GSK-3β, Wnt/β-catenin pathway | Inhibit osteoblast differentiation Inhibit osteoblast differentiation | |
Dlx3, Dlx5, and Dlx2 | ||
SFRP1 | Promote osteoblast differentiation | |
BMP-7/PI3K- survivin signaling | Inhibit osteoblast differentiation Inhibit osteoblast differentiation | |
NKIRAS2, NF-κB signaling | ||
BMPR1b | Inhibit osteoblast differentiation | |
miR-375 [32] | Runx2 | Inhibit osteoblast differentiation |
miR-100 [34] | Smad1 | Inhibit osteoblast differentiation |
miR-203a-3p [35] | Smad9, Wnt/β-catenin signaling pathway | Inhibit osteoblast differentiation |
ATF4 | Inhibit osteoblast differentiation | |
miR-153 [38] | BMPP2 | Inhibit osteoblast differentiation |
RANKL, PI3K/Akt signaling pathway, PDCD4 | Promote osteoclast differentiation | |
miR-183 [71] | RANKL, HO-1 | Promote osteoclast differentiation |
TNF-α, IL-1β, RANKL, M-CSF, RANK, TRAP, Bcl-2, LEPR, AMPK, p-AMPK, OPG, Bax, TAB 1 | Promote osteoclast differentiation | |
miR-223 [74] | TWIST and Runx2 | Promote osteoclast differentiation |
miR-19a [74] | TWIST and Runx2 | Promote osteoclast differentiation |
miR-214 [75] | Pten, PI3K/Akt pathway | Promote osteoclast differentiation |
miR-182 [76] | Foxo3, Maml1 | Promote osteoclast differentiation |
miR-26a [77] | CTGF/CCN2 | Inhibit osteoclast differentiation |
miR-31 [78] | RhoA | Inhibit osteoclast differentiation |
miRNA-17 [79] | RANKL | Inhibit osteoclast differentiation |
miR-503 [80] | RANK | Inhibit osteoclast differentiation |
PTHrP and MMP-13 | Inhibit osteoclast differentiation | |
miR-7b [83] | DC-STAMP | Inhibit osteoclast differentiation |
miR-141 [84] | Calcr, EphA2 | Inhibit osteoclast differentiation |