Fig. 5From: Tauroursodeoxycholic acid attenuates neuronal apoptosis via the TGR5/ SIRT3 pathway after subarachnoid hemorrhage in ratsThe knockdown efficiency of TGR5 siRNA. Representative Western blots (a), and TGR5 knockout worsened neurobehavioral deficits, exacerbated brain water content (b). Knockdown TGR5 abolished the anti-apoptotic effect of TUDCA after subarachnoid hemorrhage (SAH). c Representative Western blots and quantitative analyses of SIRT3, BCL-2, BAX and cleaved caspase-3. Quantified neurological scores and brain water content (d), n = 6 per group. *P < 0.05 vs sham, #P < 0.05 vs SAH + vehicle. Scr siRNA, scramble siRNABack to article page