Fig. 7
EPC-EXsmiR-17-5p increased viability, while reduced apoptosis of Hypoxia plus HG-injured C2C12 via activating PI3K/Akt pathway. A Representative images and summary data of apoptosis in C2C12. B The viability of C2C12. C The levels of Cleaved caspase-3 and Cleaved caspase-9 in ECs after incubated with EPC-EXs, EPC-EXsmiR-17-5p, and EPC-EXsmiR-17-5p + LY294002. D The diameter was measured for C2C12 myotubes (MyHc, green) treated with EPC-EXs, EPC-EXsmiR-17-5p, and EPC-EXsmiR-17-5p + LY294002. *p < 0.05 compared with the Sham group; #p < 0.05 compared with PBS group; +p < 0.05 compared with EPC-EXs group; −p < 0.05 compared with EPC-EXs.miR-17-5p group (A–D Two-way ANOVA, followed by Tukey’s post hoc test. Data represent the mean ± SEM, n = 3/group)