Fig. 6

Illustration of the roles of ncRNAs that are experimentally proved in transgenic mice models as key regulators in the molecular mechanism of OA. Nc RNAs contribute to many pathologic processes in OA, including (a) ECM degradation, (b) chondrocyte proliferation and differentiation, (c) autophagy and apoptosis, (d) angiogenesis, and (e) inflammatory events